Exactly why individuals with myocarditis don’t clear it the same way isn’t yet known, said Yonker. Typically, though, these particles don’t stick around but get cleared as the body processes the vaccine. With myocarditis, the spike protein most likely arises downstream from the vaccine itself, not leftover virus, she explained.
Lingering SARS-CoV-2 particles have been proposed as one mechanism for long COVID as well. Interestingly, said Yonker, a known feature of multisystem inflammatory syndrome in children (MIS-C), which can develop after the acute phase of COVID-19, is the persistence of viral particles in the body. We really didn’t see that at all, which surprised us,” she said. “We were expecting to see this hyper, revved up autoantibody response to the vaccine. Another possible idea had been that the mRNA COVID-19 shots trigger an overly vigorous immune response, thanks to either a genetic predisposition or testosterone. Yonker told TCTMD that, going into their study, the researchers had anticipated they would find a link between postvaccine myocarditis and autoantibodies that might be inadvertently targeting cardiac tissue.
#Spike protein vaccine free
“We discovered that individuals who developed postvaccine myocarditis uniquely exhibit elevated levels of free spike protein in circulation, unbound by antispike antibodies, which appear to correlate with cardiac troponin T levels and innate immune activation with cytokine release,” they explain, adding, “Although these findings might provide insight into the immunophenotype of vaccine-related myocarditis, they do not alter the risk-benefit ratio strongly favoring vaccination to protect against severe COVID-19-related complications.”
Yonker, MD (Massachusetts General Hospital, Boston), and colleagues turned to immunoprofiling as a way to better understand the underlying mechanisms. Prior studies have provided insight into the key clinical features of myocarditis cases, rare but real, seen with Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccines.įor their paper, published online in Circulation, Lael M. Levels of the antigen were unusually high among those with myocarditis. Instead, the complication seems related to how some individuals process spike protein, produced by the body using the vaccine’s mRNA as a template. Myocarditis that arises after receipt of an mRNA-based COVID-19 vaccine among adolescents and young adults does not appear to result from a heightened overall immune response or from autoantibodies, new data suggest.
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